Ethnic Differences in Reactions to Drugs and Xenobiotics

Ethnic differences in reactions to drugs and xenobiotics. Susceptibility to occupational and environmental exposures to chemicals.

I have presented some diverse case reports which illustrate several variations on the theme of this conference. A study of caffeine metabolites revealed two kinds of interethnic variation, one pertaining to the well-known acetylation polymorphism affecting the secondary metabolism of the parent drug; the other consisted of a difference in paraxanthine excretion which might indicate an ethnic di...

Ethnic differences in responses to disease modifying drugs.

BACKGROUND AND OBJECTIVE The UK has a growing South Asian population. In the South Asian population of Bradford people appear to be less tolerant of disease-modifying anti-rheumatic drugs (DMARDs). One reason for this may be poor communication during patient education, which is generally designed for white North European people. Our objective was to obtain information on DMARDs that were used, ...

Systematic review and meta-analysis of ethnic differences in risks of adverse reactions to drugs used in cardiovascular medicine.

OBJECTIVE To review the evidence for ethnic differences in susceptibility to adverse drug reactions (ADRs) to cardiovascular drugs. DESIGN Systematic review and meta-analysis. DATA SOURCES We searched Medline and Embase to March 2005. Reference lists of identified articles were hand searched for further relevant articles. REVIEW METHODS Studies were eligible for inclusion if they included...

N-Glucuronidation of Drugs and Other Xenobiotics

UDP-glucuronosyltransferases (UGTs) are a family of metabolic enzymes responsible for the detoxification of a wide range of endoand xenobiotics, including drugs. UGTmediated metabolism is a major determinant of the pharmacokinetic behavior of many drugs in the human body, contributing to parameters such as bioavailability and elimination. UGTs catalyze the transfer of glucuronic acid from UDP-g...

Allergic reactions to drugs.